The Ultimate American Adventure
Cruise historic waterways and awe-inspiring coastlines
- You May Qualify for One or More American Cruise Lines Offers
Our Featured Deal
-
7 Night Tennessee Rivers
American Splendor
Departing from: Chattanooga, TennesseePorts of Call:- Decatur, Alabama
- Florence, Alabama
- Savannah, Tennessee
- Paducah, Kentucky
- Clarksville, Tennessee
- Nashville, Tennessee
Sailing Dates:- August 2025
interior fromNot Availableoceanview from$4,125$589pernightbalcony from$4,635$662pernightsuite from$7,290$1,041pernightAll the Cruise Line Offers & More:Was $5,635 – Save up to 18%Riverview from $4,125($589pernight)4.1 rating out of 5 (4 reviews)
American Cruise Lines
-
7 Night Lower Mississippi River
American Splendor
Departing from: New Orleans, LouisianaPorts of Call:- Houmas House Plantation, Louisiana
- Baton Rouge, Louisiana
- St. Francisville, Louisiana
- Natchez, Mississippi
- Vicksburg, Mississippi
- River Cruising
- Memphis, Tennessee
Sailing Dates:- November 2024
interior fromNot Availableoceanview from$4,125$589pernightbalcony from$4,735$676pernightsuite from$7,365$1,052pernightAll the Cruise Line Offers & More:Was $5,125 – Save up to 20%Riverview from $4,125($589pernight)4.1 rating out of 5 (4 reviews) -
7 Night Puget Sound & San Juan Islands
American Constellation
Departing from: Seattle, WashingtonPorts of Call:- Anacortes, Washington
- Friday Harbor, San Juan Island, Washington
- Cruise San Juan Islands
- Victoria, British Columbia
- Port Townsend, Washington
- Poulsbo, Washington
Sailing Dates:- October 2024
- April 2025
- May 2025
interior fromNot Availableoceanview from$4,585$655pernightbalcony from$5,405$772pernightsuite from$6,935$991pernightAll the Cruise Line Offers & More:Was $6,405 – Save up to 16%Riverview from $4,585($655pernight)4.9 rating out of 5 (7 reviews) -
7 Night Columbia & Snake Rivers
American Pride
Departing from: Portland, OregonPorts of Call:- Hayden Island, Portland, Oregon
- Astoria, Oregon
- Mount St. Helens, Washington
- Cruise Columbia River, Pacific Northwest, Usa
- The Dalles, Oregon
- Pendleton, Oregon
- Cruise Snake River, Pacific Northwest, Usa
- Clarkston, Washington
Sailing Dates:- October 2024
interior fromNot Availableoceanview from$4,825$689pernightbalcony from$5,515$788pernightsuite from$8,730$1,247pernightAll the Cruise Line Offers & More:Riverview from $4,825($689pernight)4.4 rating out of 5 (7 reviews) -
7 Night Music Cities
American Melody
Departing from: Nashville, TennesseePorts of Call:- Clarksville, Tennessee
- Dover, Tennessee
- River Cruising
- Paducah, Kentucky
- River Cruising
- Memphis, Tennessee
Sailing Dates:- November 2024
interior fromNot Availableoceanview fromNot Availablebalcony from$5,075$725pernightsuite from$7,005$1,001pernightAll the Cruise Line Offers & More:Was $6,075 – Save up to 16%Balcony from $5,075($725pernight)5 rating out of 5 (8 reviews) -
7 Night Tennessee Rivers
American Serenade
Departing from: Chattanooga, TennesseePorts of Call:- Decatur, Alabama
- Florence, Alabama
- Savannah, Tennessee
- Paducah, Kentucky
- Clarksville, Tennessee
- Nashville, Tennessee
Sailing Dates:- October 2024
interior fromNot Availableoceanview fromNot Availablebalcony from$5,075$725pernightsuite from$7,005$1,001pernightAll the Cruise Line Offers & More:Was $6,075 – Save up to 16%Balcony from $5,075($725pernight) -
7 Night Lower Mississippi River
American Symphony
Departing from: New Orleans, LouisianaPorts of Call:- Houmas House Plantation, Louisiana
- Baton Rouge, Louisiana
- St. Francisville, Louisiana
- Natchez, Mississippi
- Vicksburg, Mississippi
- River Cruising
- Memphis, Tennessee
Sailing Dates:- November 2024
- December 2024
interior fromNot Availableoceanview fromNot Availablebalcony from$5,075$725pernightsuite from$7,005$1,001pernightAll the Cruise Line Offers & More:Was $6,075 – Save up to 16%Balcony from $5,075($725pernight)4.2 rating out of 5 (4 reviews) -
7 Night Lower Mississippi River
American Melody
Departing from: Memphis, TennesseePorts of Call:- River Cruising
- Vicksburg, Mississippi
- Natchez, Mississippi
- St. Francisville, Louisiana
- Baton Rouge, Louisiana
- Houmas House Plantation, Louisiana
- New Orleans, Louisiana
Sailing Dates:- November 2024
interior fromNot Availableoceanview fromNot Availablebalcony from$5,390$770pernightsuite from$7,005$1,001pernightAll the Cruise Line Offers & More:Was $6,390 – Save up to 16%Balcony from $5,390($770pernight)5 rating out of 5 (8 reviews) -
7 Night Lower Mississippi River
American Symphony
Departing from: Memphis, TennesseePorts of Call:- River Cruising
- Vicksburg, Mississippi
- Natchez, Mississippi
- St. Francisville, Louisiana
- Baton Rouge, Louisiana
- Houmas House Plantation, Louisiana
- New Orleans, Louisiana
Sailing Dates:- October 2024
- December 2024
interior fromNot Availableoceanview fromNot Availablebalcony from$5,075$725pernightsuite from$7,005$1,001pernightAll the Cruise Line Offers & More:Was $6,075 – Save up to 16%Balcony from $5,075($725pernight)4.2 rating out of 5 (4 reviews) -
7 Night Columbia & Snake Rivers
American Harmony
Departing from: Portland, OregonPorts of Call:- Hayden Island, Portland, Oregon
- Astoria, Oregon
- Mount St. Helens, Washington
- Cruise Columbia River, Pacific Northwest, Usa
- The Dalles, Oregon
- Pendleton, Oregon
- Cruise Snake River, Pacific Northwest, Usa
- Clarkston, Washington
Sailing Dates:- May 2025
interior fromNot Availableoceanview fromNot Availablebalcony from$5,990$856pernightsuite from$8,355$1,194pernightAll the Cruise Line Offers & More:Was $6,990 – Save up to 14%Balcony from $5,990($856pernight)5 rating out of 5 (6 reviews) -
7 Night Southeast Alaska
American Constellation
Departing from: Juneau, AlaskaPorts of Call:- Haines, Alaska
- Glacier Bay National Park, Alaska (Scenic Cruising)
- Petersburg, Alaska
- Cruise Wrangell Narrows, Alaska
- Wrangell, Alaska
- Cruise Tracy Arm Fjord, Alaska
Sailing Dates:- May 2025
- June 2025
- July 2025
- August 2025
- September 2025
interior fromNot Availableoceanview from$6,150$879pernightbalcony from$7,245$1,035pernightsuite from$9,300$1,329pernightAll the Cruise Line Offers & More:Was $8,245 – Save up to 12%Riverview from $6,150($879pernight)4.9 rating out of 5 (7 reviews) -
10 Night Alaskan Explorer
American Constellation
Departing from: Juneau, AlaskaPorts of Call:- Haines, Alaska
- Cruise Inside Passage, Alaska
- Glacier Bay National Park, Alaska (Scenic Cruising)
- Sitka, Alaska
- Wrangell, Alaska
- Cruise Wrangell Narrows, Alaska
- Petersburg, Alaska
- Cruise Inside Passage, Alaska
- Cruise Tracy Arm Fjord, Alaska
Sailing Dates:- June 2025
- July 2025
- August 2025
interior fromNot Availableoceanview from$8,760$876pernightbalcony from$10,325$1,033pernightsuite from$13,180$1,318pernightAll the Cruise Line Offers & More:Was $11,325 – Save up to 9%Riverview from $8,760($876pernight)4.9 rating out of 5 (7 reviews) -
14 Night Alaska Inside Passage
American Constellation
Departing from: Seattle, WashingtonPorts of Call:- Anacortes, Washington
- Friday Harbor, San Juan Island, Washington
- Cruise Queen Charlotte Sound, British Columbia
- Cruise Inside Passage, Alaska
- Ketchikan, Alaska
- Wrangell, Alaska
- Petersburg, Alaska
- Cruise Tracy Arm Fjord, Alaska
- Cruise Glacier Bay National Park
- Haines, Alaska
- Skagway, Alaska
- Juneau, Alaska
Sailing Dates:- May 2025
interior fromNot Availableoceanview from$10,385$742pernightbalcony from$12,240$874pernightsuite from$15,570$1,112pernightAll the Cruise Line Offers & More:Was $11,385 – Save up to 9%Riverview from $10,385($742pernight)4.9 rating out of 5 (7 reviews)
American Cruise Line River Cruises
Request a Consultation
Our Personal Cruise Concierges can help you find the perfect luxury cruise with the best savings and extras, including an exclusive bonus just for booking with Cruises.com. Plus, we'll take care of all your travel needs - flight and hotel bookings, onboard reservations, and beyond - so all you have to do is pack.
Simply complete the form and a concierge will contact you shortly.
1-888-999-32711-888-999-3271 9AM to 8PM Monday through Friday, 9AM to 6PM Saturday through Sunday eastern standard time